Your heart

The clinical symptoms of candidemia or acute disseminated candidiasis are not specific. The most common symptom is a fever that persists or occurs repeatedly during therapy with broad-spectrum antibiotics. In 10-15% of cases occur dermal (screenings) in the form of discrete, small, size 0,3-0,6 cm papular formations pinkish-reddish color, or subcutaneous abscesses. Another feature characteristic of invasive candidiasis (Candida sepsis) - rather an expression of pain in the muscles that bother patients at rest - is rarely recorded. Endophthalmitis with candidemia occur in 9-15% of patients. Clinical symptoms include decreased visual acuity until the development of blindness in the fundus reveals whitish coating. All patients with candidemia should be ophthalmoscopy with dilated [7].

Mortality in candidaemia remains high, accounting for 40%. The minimum frequency of deaths registered with infections caused by C. parapsilosis (7-8%), the maximum - in infections caused by C. glabrata (45%). In acute disseminated candidiasis die of 70-80% of patients.

The defeat of Candida lung occurs mainly due to hematogenous dissemination of fungi, rarely being the primary manifestation of candidiasis (Candida aspiration of the pharynx). Diagnosis pnevmokandidoza difficult. The X-ray marked decrease in the transparency of lung tissue, it seems the presence of small multiple foci. In these cases, conduct computed tomography of the lungs. For pnevmokandidoza characterized by the presence of multiple small foci located at the periphery of lung fields. Clinical symptoms are nonspecific, sometimes it can disturb a dry cough.

Invasion of the yeast central nervous system occurs in the form of destruction of shells of matter and cerebral vessels, often complicating the healing process in patients with ventriculo-peritoneal shunts. Clinically manifest meningitis, encephalitis, brain abscesses, mycotic aneurysm.

Candida endocarditis is more common in patients undergoing heart valve brand viagra replacement or had previously damaged (vegetation) on the valves of the heart other infectious nature. Predisposing factors in the development of this pathology is a central venous catheter, intravenous injection of drugs (drug addicts). When Candida endocarditis most often, 40% of the cases involved the aortic valve, and then - the mitral, at least - tricuspid, the drug most often - tricuspid valve. The clinical picture of candidiasis and bacterial endocarditis is similar. For Candida endocarditis is characterized by a high frequency of emboli. Coronary embolism fungi leads to the development of ischemia or myocardial infarction. 60% of patients diagnosed with endocarditis is established only at autopsy. Approximately 80% of patients with endocarditis revealed a positive growth of Candida in blood culture.

The defeat of Candida joints observed in hematogenous dissemination of infection or intra-articular administration of glucocorticoids. Such infection occurs primarily in patients with rheumatoid arthritis and patients with foreign intraarticular devices. Often affects the knee joint, common symptoms of inflammation are often absent, the infectious process in most cases is manifested by local symptoms. Diagnosis is made on the basis of isolation of fungi (crops) of the juxta-articular fluid. Timely diagnosis, surgical treatment (removal of lymph, drainage) and antimycotic therapy can prevent the onset of destruction of articular cartilage.

Most cases of Candida osteomyelitis, except in cases of fungal lesions of the sternum, resulting in its operative dissection (sternotomy) is a consequence of hematogenous spread of infection. Often in the infectious process involved vertebrae. Back pain, fever, radicular syndrome occur in this pathology. Carried out drainage foci and appointed fluconazole.

Peritonitis and abscesses itraabdominalnye

Isolation of Candida spp. from peritoneal fluid obtained by aspiration or during surgery, patients with intra-abdominal abscess or peritonitis indicates intestinal perforation, or is the result of contamination in the digestive tract anastomotic failure [8]. Candida peritonitis occurs more often in tumors of the digestive tract, anastomotic failure, intestinal perforation, urgent relaparotomy, liver cirrhosis, pancreatitis, pancreatic necrosis [6,8]. Patients with Candida peritonitis or abscesses candidal etiology confirmed by mycological examination (detection of fungal elements on microscopy and / or evolution of culture Candida spp.), Along with surgical treatment is carried out systemic therapy with antifungal drugs. Treatment antibakterilnymi drug continues because of poly etiology of abdominal infections. Clinical manifestations of Candida peritonitis and bakterilnogo identical.

knowledge
many years
start and maintain
multivitamin
abortive clinical